|
Tumor Progression
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
While it has been presumed that the mechanism by which LIMK1 promotes cancer progression is via its cytoplasmic effects, the role of nuclear vs cytoplasmic LIMK1 in the tumorigenic process has not been examined.
|
21682918 |
2011 |
|
Huntington Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
We investigated the messenger RNA (mRNA) expression of Rho kinase pathway genes, including RhoA (Ras homolog family member A), ROCK1 (Rho-associated kinase1), PRK2 (protein kinase C-related protein kinase 2), Profilin1, cofilin1, MYPT1 (myosin phosphatase target subunit 1), and LIMK1 (LIM domain kinase 1) in HD human blood leukocytes, postmortem brain, and in R6/2 HD mouse brain tissue using qPCR.
|
25941073 |
2016 |
|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
We have also noted increased nuclear staining of LIMK1 in tumors with higher Gleason Scores and incidence of metastasis.
|
17559677 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We have also noted increased nuclear staining of LIMK1 in tumors with higher Gleason Scores and incidence of metastasis.
|
17559677 |
2007 |
|
Endometriosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found that, before LIMK1silencing, the phosphorylation levels of cofilin1 and LIMK1 of eutopic endometrial stromal cells from endometriosis patients treated with estradiol were higher than cells not treated with estradiol (<i>P</i> < .05 and <i>P</i> < .01, respectively).
|
30808273 |
2019 |
|
Intracranial Aneurysm
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
We found that the SNPs of LOXL2 have an interactive effect with elastin (ELN) and LIM kinase 1 (LIMK1) that have been previously found to be associated with IA.
|
17287949 |
2007 |
|
Malignant neoplasm of prostate
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
We found that the level and activity of endogenous LIMK1 is increased in invasive breast and prostate cancer cell lines in comparison with less invasive cells.
|
12777619 |
2003 |
|
Prostate carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
We found that the level and activity of endogenous LIMK1 is increased in invasive breast and prostate cancer cell lines in comparison with less invasive cells.
|
12777619 |
2003 |
|
Malignant neoplasm of thyroid
|
0.010 |
Biomarker
|
disease |
BEFREE |
We found that LIMK1 was a target of miR-20a in thyroid cancer cell lines and direct knockdown of LIMK1 recapitulated the effect of miR-20a in thyroid cancer cells.
|
24858712 |
2014 |
|
Thyroid Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
We found that LIMK1 was a target of miR-20a in thyroid cancer cell lines and direct knockdown of LIMK1 recapitulated the effect of miR-20a in thyroid cancer cells.
|
24858712 |
2014 |
|
Thyroid carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We found that LIMK1 was a target of miR-20a in thyroid cancer cell lines and direct knockdown of LIMK1 recapitulated the effect of miR-20a in thyroid cancer cells.
|
24858712 |
2014 |
|
Atrial Fibrillation
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found that AF patients had upregulated expression of LIMK1 as well as higher fibrosis.
|
30837367 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We analyzed here the metastatic behavior and tumor cell-induced neovascularization of pancreatic cancer cells in which both LIMK genes were silenced by siRNAs.
|
20047470 |
2009 |
|
Prostatic Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
We also noted increased expression of both MT1-MMP and LIMK1 in prostate tumor tissues.
|
21219645 |
2011 |
|
Chronic heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
Upregulation of miR-93 and inhibition of LIMK1 improve ventricular remodeling and alleviate cardiac dysfunction in rats with chronic heart failure by inhibiting RhoA/ROCK signaling pathway activation.
|
31541994 |
2019 |
|
Tumor Cell Invasion
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Tβ4 overexpression augmented in vitro invasion and MMP-2 activity and enhanced the phosphorylation of paxillin and cortactin and expression of LIMK1.
|
26276576 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumors derived from LIMK1/2 knockdown TICs were substantially smaller and showed delayed growth kinetics and more distinct margins than tumors derived from control TICs.
|
31641031 |
2020 |
|
Non-Small Cell Lung Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Together, our results highlight the significance of miR-143 and Limk1 in the development and progression of NSCLC.
|
25003638 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
To our knowledge, this is the first study to demonstrate that miR-20a plays a role as a tumor suppressor in thyroid cancer cells and targets LIMK1.
|
24858712 |
2014 |
|
Osteosarcoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
To observe the expression pattern of LIMK1 in osteosarcoma, immunohistochemical analyses were performed on specimens derived from 6 patients.
|
29387219 |
2018 |
|
Osteosarcoma of bone
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
To observe the expression pattern of LIMK1 in osteosarcoma, immunohistochemical analyses were performed on specimens derived from 6 patients.
|
29387219 |
2018 |
|
Childhood Osteosarcoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
To observe the expression pattern of LIMK1 in osteosarcoma, immunohistochemical analyses were performed on specimens derived from 6 patients.
|
29387219 |
2018 |
|
Malignant neoplasm of breast
|
0.070 |
Biomarker
|
disease |
BEFREE |
To investigate the respective roles of cytoplasmic and nuclear LIMK1 in breast cancer progression, we targeted GFP-LIMK1 to cytoplasmic and nuclear subcellular compartments by fusing nuclear export signals (NESs) or nuclear localization sequences (NLS), respectively, to the amino-terminus of GFP-LIMK1.
|
21682918 |
2011 |
|
Breast Carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
To investigate the respective roles of cytoplasmic and nuclear LIMK1 in breast cancer progression, we targeted GFP-LIMK1 to cytoplasmic and nuclear subcellular compartments by fusing nuclear export signals (NESs) or nuclear localization sequences (NLS), respectively, to the amino-terminus of GFP-LIMK1.
|
21682918 |
2011 |
|
Williams Syndrome
|
0.600 |
Biomarker
|
disease |
BEFREE |
To determine the role of LIMK1 in the highly penetrant visuospatial deficits associated with classic WS, it is essential to investigate the discrepancies between the two studies.
|
16216290 |
2006 |