LIMK1, LIM domain kinase 1, 3984

N. diseases: 271; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.060 Biomarker phenotype BEFREE While it has been presumed that the mechanism by which LIMK1 promotes cancer progression is via its cytoplasmic effects, the role of nuclear vs cytoplasmic LIMK1 in the tumorigenic process has not been examined. 21682918 2011
CUI: C0020179
Disease: Huntington Disease
Huntington Disease
0.010 Biomarker disease BEFREE We investigated the messenger RNA (mRNA) expression of Rho kinase pathway genes, including RhoA (Ras homolog family member A), ROCK1 (Rho-associated kinase1), PRK2 (protein kinase C-related protein kinase 2), Profilin1, cofilin1, MYPT1 (myosin phosphatase target subunit 1), and LIMK1 (LIM domain kinase 1) in HD human blood leukocytes, postmortem brain, and in R6/2 HD mouse brain tissue using qPCR. 25941073 2016
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 Biomarker phenotype BEFREE We have also noted increased nuclear staining of LIMK1 in tumors with higher Gleason Scores and incidence of metastasis. 17559677 2007
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker group BEFREE We have also noted increased nuclear staining of LIMK1 in tumors with higher Gleason Scores and incidence of metastasis. 17559677 2007
CUI: C0014175
Disease: Endometriosis
Endometriosis
0.010 AlteredExpression disease BEFREE We found that, before LIMK1silencing, the phosphorylation levels of cofilin1 and LIMK1 of eutopic endometrial stromal cells from endometriosis patients treated with estradiol were higher than cells not treated with estradiol (<i>P</i> < .05 and <i>P</i> < .01, respectively). 30808273 2019
CUI: C0007766
Disease: Intracranial Aneurysm
Intracranial Aneurysm
0.040 GeneticVariation disease BEFREE We found that the SNPs of LOXL2 have an interactive effect with elastin (ELN) and LIM kinase 1 (LIMK1) that have been previously found to be associated with IA. 17287949 2007
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.030 AlteredExpression disease BEFREE We found that the level and activity of endogenous LIMK1 is increased in invasive breast and prostate cancer cell lines in comparison with less invasive cells. 12777619 2003
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.030 AlteredExpression disease BEFREE We found that the level and activity of endogenous LIMK1 is increased in invasive breast and prostate cancer cell lines in comparison with less invasive cells. 12777619 2003
CUI: C0007115
Disease: Malignant neoplasm of thyroid
Malignant neoplasm of thyroid
0.010 Biomarker disease BEFREE We found that LIMK1 was a target of miR-20a in thyroid cancer cell lines and direct knockdown of LIMK1 recapitulated the effect of miR-20a in thyroid cancer cells. 24858712 2014
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm
0.010 Biomarker disease BEFREE We found that LIMK1 was a target of miR-20a in thyroid cancer cell lines and direct knockdown of LIMK1 recapitulated the effect of miR-20a in thyroid cancer cells. 24858712 2014
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.010 Biomarker disease BEFREE We found that LIMK1 was a target of miR-20a in thyroid cancer cell lines and direct knockdown of LIMK1 recapitulated the effect of miR-20a in thyroid cancer cells. 24858712 2014
CUI: C0004238
Disease: Atrial Fibrillation
Atrial Fibrillation
0.010 AlteredExpression disease BEFREE We found that AF patients had upregulated expression of LIMK1 as well as higher fibrosis. 30837367 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker group BEFREE We analyzed here the metastatic behavior and tumor cell-induced neovascularization of pancreatic cancer cells in which both LIMK genes were silenced by siRNAs. 20047470 2009
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.030 AlteredExpression group BEFREE We also noted increased expression of both MT1-MMP and LIMK1 in prostate tumor tissues. 21219645 2011
CUI: C0264716
Disease: Chronic heart failure
Chronic heart failure
0.010 Biomarker disease BEFREE Upregulation of miR-93 and inhibition of LIMK1 improve ventricular remodeling and alleviate cardiac dysfunction in rats with chronic heart failure by inhibiting RhoA/ROCK signaling pathway activation. 31541994 2019
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 AlteredExpression phenotype BEFREE Tβ4 overexpression augmented in vitro invasion and MMP-2 activity and enhanced the phosphorylation of paxillin and cortactin and expression of LIMK1. 26276576 2016
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker group BEFREE Tumors derived from LIMK1/2 knockdown TICs were substantially smaller and showed delayed growth kinetics and more distinct margins than tumors derived from control TICs. 31641031 2020
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.050 Biomarker disease BEFREE Together, our results highlight the significance of miR-143 and Limk1 in the development and progression of NSCLC. 25003638 2014
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker group BEFREE To our knowledge, this is the first study to demonstrate that miR-20a plays a role as a tumor suppressor in thyroid cancer cells and targets LIMK1. 24858712 2014
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma
0.030 AlteredExpression disease BEFREE To observe the expression pattern of LIMK1 in osteosarcoma, immunohistochemical analyses were performed on specimens derived from 6 patients. 29387219 2018
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.030 AlteredExpression disease BEFREE To observe the expression pattern of LIMK1 in osteosarcoma, immunohistochemical analyses were performed on specimens derived from 6 patients. 29387219 2018
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma
0.030 AlteredExpression disease BEFREE To observe the expression pattern of LIMK1 in osteosarcoma, immunohistochemical analyses were performed on specimens derived from 6 patients. 29387219 2018
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.070 Biomarker disease BEFREE To investigate the respective roles of cytoplasmic and nuclear LIMK1 in breast cancer progression, we targeted GFP-LIMK1 to cytoplasmic and nuclear subcellular compartments by fusing nuclear export signals (NESs) or nuclear localization sequences (NLS), respectively, to the amino-terminus of GFP-LIMK1. 21682918 2011
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.070 Biomarker disease BEFREE To investigate the respective roles of cytoplasmic and nuclear LIMK1 in breast cancer progression, we targeted GFP-LIMK1 to cytoplasmic and nuclear subcellular compartments by fusing nuclear export signals (NESs) or nuclear localization sequences (NLS), respectively, to the amino-terminus of GFP-LIMK1. 21682918 2011
CUI: C0175702
Disease: Williams Syndrome
Williams Syndrome
0.600 Biomarker disease BEFREE To determine the role of LIMK1 in the highly penetrant visuospatial deficits associated with classic WS, it is essential to investigate the discrepancies between the two studies. 16216290 2006